This paper aims to identify the most influential trends in the design of creative work-places in the fourth-generation industry. The scope of research covered several design aspects, ranging from location issues to detailed functional solutions of the factory and details of the architectural design. Due to its applicable nature, the research-by-design method was combined with didactic classes. The research results showed the multifaceted influence of Iindustry 4.0 concept on the architectural design of industrial plants. The new factory models' most important functional and spatial features were characterized in relation to the work organization scenario. The research results also highlighted the critical importance of analytical skills in architectural design, translating into applying conclusions in practice and the didactic field.