Biophilia hypothesis based on the inherent human affinity to affiliate with the natural systems and biophilic design that introduces its consideration into the design methodology of the built environment, has been critically analyzed since the 90. XX. This paper refers to the biophilia concept in the context of the interior architectural design. The analyzed design methods and techniques in shaping of the interior environment’s components recognize the patterns and attributes of the biophilic design. Their application into the design methodology, as essential design determinants, indirectly impacts the fulfillment of the sustainability postulates. These consider the optimization of indoor quality parameters, including the user’s satisfaction on the emotional, aesthetical and cognitive levels. This paper attempts to revise the interior architectural design methodology and to prove that consequent enclosure of the elements of biophilia concept is to extend the scope of the notion of environmental sustainability, as well as to stimulate the innovative solutions for architectural interiors and their components.